1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate
1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate
CAS: 1160293-27-5
Molecular Formula: C13H13NO8
1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate - Names and Identifiers
1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate - Physico-chemical Properties
| Molecular Formula | C13H13NO8 |
| Molar Mass | 311.24422 |
| Density | 1.357±0.06 g/cm3(Predicted) |
| Melting Point | 65 - 68°C |
| Boling Point | 433.1±40.0 °C(Predicted) |
| Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| Appearance | Solid |
| Color | Pale Yellow to Light Yellow |
| pKa | 9.81±0.46(Predicted) |
| Storage Condition | Refrigerator, under inert atmosphere |
1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate - Upstream Downstream Industry
| Raw Materials | Methyl 4-chloro-3-nitrobenzoate Dimethyl malonate 4-Chloro-3-nitrobenzoic acid |
| Downstream Products | 2,3-Dihydro-3-(MethoxyphenylMethylene)-2-oxo-1H-indole-6-carboxylic acid Methyl ester |
1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate - Introduction
Dimethyl 1,3-dimethyl -2-[4-(methoxycarbonyl)-2-nitrophenyl] malonate is an organic compound with the chemical formula C14H15NO7, the molecular weight was 301.27g/mol.
Nature:
-Appearance: White solid
-Melting point: 98-102 ° C
-Boiling point: 379.3 ° C
-Soluble: Slightly soluble in water, soluble in organic solvents such as ether, ethanol and dichloromethane
Use:
1,3-dimethyl -2-[4-(methoxycarbonyl)-2-nitrophenyl] malonic acid dimethyl ester can be used as an organic synthesis intermediate, it is often used in the preparation of active molecules such as drugs or pesticides. It can be used as a raw material for the synthesis of aromatic compounds and has great application potential.
Method:
Dimethyl 1,3-dimethyl -2-[4-(methoxycarbonyl)-2-nitrophenyl] malonate can be synthesized by the following steps:
1.2-nitro -4-methoxycarbonyl benzoic acid is converted into 2-nitro -4-methyl benzoic anhydride by anhydridization reaction;
2. 2-Nitro-4-methylbenzoic anhydride is reacted with dimethyl malonate to give dimethyl 1,3-dimethyl -2-[4-(methoxycarbonyl)-2-nitrophenyl] malonate.
Safety Information:
Dimethyl 1,3-dimethyl -2-[4-(methoxycarbonyl)-2-nitrophenyl] malonate is generally a relatively safe compound under regular conditions of use. However, any chemical substance should be handled with caution. Appropriate laboratory safety measures, such as wearing protective gloves, glasses and laboratory coats, should be taken during handling or contact. If skin contact or inhalation occurs, wash immediately or seek medical help. Safety regulations for chemicals should be observed during handling and storage.
Nature:
-Appearance: White solid
-Melting point: 98-102 ° C
-Boiling point: 379.3 ° C
-Soluble: Slightly soluble in water, soluble in organic solvents such as ether, ethanol and dichloromethane
Use:
1,3-dimethyl -2-[4-(methoxycarbonyl)-2-nitrophenyl] malonic acid dimethyl ester can be used as an organic synthesis intermediate, it is often used in the preparation of active molecules such as drugs or pesticides. It can be used as a raw material for the synthesis of aromatic compounds and has great application potential.
Method:
Dimethyl 1,3-dimethyl -2-[4-(methoxycarbonyl)-2-nitrophenyl] malonate can be synthesized by the following steps:
1.2-nitro -4-methoxycarbonyl benzoic acid is converted into 2-nitro -4-methyl benzoic anhydride by anhydridization reaction;
2. 2-Nitro-4-methylbenzoic anhydride is reacted with dimethyl malonate to give dimethyl 1,3-dimethyl -2-[4-(methoxycarbonyl)-2-nitrophenyl] malonate.
Safety Information:
Dimethyl 1,3-dimethyl -2-[4-(methoxycarbonyl)-2-nitrophenyl] malonate is generally a relatively safe compound under regular conditions of use. However, any chemical substance should be handled with caution. Appropriate laboratory safety measures, such as wearing protective gloves, glasses and laboratory coats, should be taken during handling or contact. If skin contact or inhalation occurs, wash immediately or seek medical help. Safety regulations for chemicals should be observed during handling and storage.
Last Update：2024-04-09 20:45:29
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CAS: 1160293-27-5
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Raw Materials for 1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate
Downstream Products for 1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate